The Journal of Cannabis in Clinical Practice
Are you guys hip to this? I wasn’t ’til just the other day when a friend of mine dropped off a copy of the Autumn 2011 edition. There’s some good stuff in there, man. If you are an individual administering cannabis medicinally I’d highly recommend you get your hands on one.
CBD and “minor” cannabinoids are a big topic in the issue (which I’m not done with yet, by the way). The SCC (Society of Cannabis Clinicians) has begun what they call “Project CBD.” It’s a survey, of sorts, to be answered by folks who use cannabis medicinally and know the average CBD content of the strain they’re utilizing.
I’m beginning to understand how difficult it is to do science with a substance containing (at least) 66 active molecules (compounds?). And it doesn’t stop there.
Terpenes (or terpenoids) are suspected to be a player, too. O’Shaughnessy’s gets into this whole “entourage effect” thing. That is, a single cannabinoid can be administered and an effect observed. This effect can be positive or negative (see Rimonabant). Add another cannabinoid in the mix and results could very well differ. The cannabinoids are like a crew, man. One can bang away on this or that, but without shoring, support, procurement… This is why (in my opinion) phytocannabinoids are such a bitch for big pharma. At least GW pharmaceuticals had enough sense to use two cannabinoids, eh?
O’Shaugnessy’s is real world, too. I mean, the group understands that people are medicating with whole plant cannabis; smoking it, vaporizing, eating it… They don’t shy away from that “stigma”.
Somehow I got the impression if I used young flowers for my capsules I’d have a higher CBD content. Nope. It doesn’t work that way. I haven’t the equipment (nor the money) to do the testing, but I might be harvesting CBG (cannabigerol) rich material. I’m okay with that. CBG acts as a GABA reuptake inhibitor. That works as a muscle relaxant, spasm relief, an analgesic and stuff.
Side effects can result in lethargy, confusion, cognitive and memory impairment… I’ve experienced that. That’s why I take the caps every third night and I’m still experimenting with the formulation. I do wish I had the equipment to test both me and the material I’m using sigh.
Oh! And did you know that CBD isn’t really active at the CB receptors? What it does is suppress FAAH (Fatty Acid Amide Hydroxylase). FAAH is the enzyme that breaks down anandamide.
I love this shit, man.
Transient Receptor Potential cation channel subfamily V (TRPV). Grab a copy of “O’s” and you’ll know why you might have some interest in TRPV’s.
Love this shit…