I’m a nerve guy. I can talk about action potentials and sheaths and nodes and sodium/potassium pumps and axons and dendrites and synapses (both axoaxonic and axosomatic) and… stuff. My malady is nerve related. Sorta.
The “sorta” didn’t dawn on me ’til an associate sent me a link about the roles played by the CB1 and 2 system in the remodeling of bone. You know… my pissed off nerves wouldn’t be, if it weren’t for the fucked up bone; stenosis, osteophytes, osteoarthritis? It aint the nerves. They’re just the messengers. It’s the bone.
The nerves would be fine if it weren’t for the bone.
I need to expand my studies.
Osteoblasts and osteoclasts. Remember those. Blasts make bone. Clasts absorb bone. This is going on within you. Right now. As you read this. Cool, huh?
Bone is important to people. The fact that it’s in constant rejuvenation is very important to the bone. Especially for bones of older folks; men whose testosterone levels drop off, women after menopause – when those hormones, too, drop to lower levels. Those hormones have a big influence on bone. Things can get out of kilter.
I’m reminded of a joke about how to make a hormone…
Osteoporosis. That’s what we’re talking about here: Osteoporosis and the endocannabinoid system.
Here, check this out:
I think what that reads is there’s strong evidence manipulating the CB1 and CB2 systems can interfere with an osteoblast kicking off the precursors to form osteoclasts and, also, induce apoptosis (cell death) in osteoblasts.
Finding the CB1 system associated with bone confused me at first. I typically associate the CB1 with the brain, major organs, and the peripheral nerves. Then I considered bones as organs. Then I remembered the thigh bone is connected to the knee bone connected to the shin bone…
Where the hell did that come from? Heh!
Hormones. CB1 & 2. Neuroactive receptors… bone physiology.
The article is rather heavy. In reviewing it I’ve spent several hours with a search engine running in the background. Like, everyone knows what RANKL is, right? Yeah, right. If you find yourself with some free time and wouldn’t mind taking a quick biology course, check it out in-depth. Have your reference materials handy.
…weird it starts out talking about treating addiction with THC.